A fundamental role for interleukin-21 in the generation of T follicular helper cells.

@article{Vogelzang2008AFR,
  title={A fundamental role for interleukin-21 in the generation of T follicular helper cells.},
  author={Alexis Vogelzang and Helen M McGuire and Di Yu and Jonathan Sprent and Charles R Mackay and C Christopher King},
  journal={Immunity},
  year={2008},
  volume={29 1},
  pages={127-37}
}
T cell help to B cells is a fundamental property of adaptive immunity, yet only recently have many of the cellular and molecular mechanisms of T cell help emerged. T follicular helper (Tfh) cells are the CD4(+) T helper cells that provide cognate help to B cells for high-affinity antibody production in germinal centers (GC). Tfh cells produce interleukin-21 (IL-21), and we show that IL-21 was necessary for GC formation. However, the central role of IL-21 in GC formation reflected its effects on… CONTINUE READING
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