A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

@article{Coombes2007AFS,
  title={A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism},
  author={J L Coombes and Karima R.R. Siddiqui and Carolina V. Arancibia-C{\'a}rcamo and Jason Hall and Cheng-Ming Sun and Yasmine Belkaid and Fiona Powrie},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={1757 - 1764}
}
Foxp3(+) regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory activity in the thymus, but there is also evidence for development of Foxp3(+) T reg cells from naive precursors in the periphery. Recent studies have shown that transforming growth factor (TGF)-beta can promote T reg cell development in culture, but little is known about the cellular and molecular mechanisms that mediate this pathway under more physiological… CONTINUE READING
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