A functionally relevant and long-term model of deep brain stimulation of the rat subthalamic nucleus: advantages and considerations.

@article{SpielesEngemann2010AFR,
  title={A functionally relevant and long-term model of deep brain stimulation of the rat subthalamic nucleus: advantages and considerations.},
  author={Anne L. Spieles-Engemann and Timothy J. Collier and Caryl E Sortwell},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 7},
  pages={1092-9}
}
In this review we outline some relevant considerations with regards to the rat model of deep brain stimulation of the subthalamic nucleus (STN DBS). In order to optimize the rat STN DBS model in terms of predictive validity for the clinical situation we propose that the STN stimulation experimental design parameters in rodents should incorporate the following features: (i) stimulation parameters that demonstrate functional alleviation of symptoms induced by nigrostriatal dopamine (DA… CONTINUE READING