A functionally inactive p53 Li-Fraumeni syndrome mutant.

Abstract

Germline mutations in the tumor-suppressor p53 have been recently identified in Li-Fraumeni syndrome patients. We analysed the function of one of these mutations, an arg-to-trp substitution at amino acid 245 in the murine p53 gene. This p53LFS mutant could not, unlike wild-type p53, suppress foci formation of rat embryo-fibroblasts. Like other p53 mutants… (More)

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Cite this paper

@article{Hao1993AFI, title={A functionally inactive p53 Li-Fraumeni syndrome mutant.}, author={Ming Hao and Claire Finlay and Guillermina Lozano}, journal={Oncogene}, year={1993}, volume={8 2}, pages={299-306} }