A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.

@article{Villard2000AFE,
  title={A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.},
  author={Jean Villard and Marie Peretti and Krzysztof Masternak and Emmanu{\`e}le Barras and Giuseppina Caretti and Roberto Mantovani and Walter Reith},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 10},
  pages={3364-76}
}
Major histocompatibility complex class II (MHC-II) molecules occupy a pivotal position in the adaptive immune system, and correct regulation of their expression is therefore of critical importance for the control of the immune response. Several regulatory factors essential for the transcription of MHC-II genes have been identified by elucidation of the molecular defects responsible for MHC-II deficiency, a hereditary immunodeficiency disease characterized by regulatory defects abrogating MHC-II… CONTINUE READING

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