A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.

@article{Prakasam2005AFV,
  title={A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.},
  author={Ramachandran Prakasam and Takahashi Kadowaki and Atsuyo Baba and Takayuki Tsukuba and Kenji Yamamoto},
  journal={Infection and immunity},
  year={2005},
  volume={73 2},
  pages={
          883-93
        }
}
Arg-gingipain (Rgp) and Lys-gingipain (Kgp) are Porphyromonas gingivalis cysteine proteinases implicated as major virulence factors in pathologies of periodontitis. We purified a 660-kDa cell-associated gingipain complex existing as a homodimer of two catalytically active monomers which comprises their catalytic and adhesin domains. Electron microscopy revealed that the complex was composed of a globular particle with a 10-nm external diameter possessing one or two electron-dense hole-like… CONTINUE READING
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