A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection.

@article{Berres2009AFV,
  title={A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection.},
  author={M E Berres and Sven Papen and Katrin Pauels and Petra Schmitz and Mirko Moreno Zaldivar and Claus Hellerbrand and Tobias Carsten M{\"u}ller and Thomas Berg and Ralf Weiskirchen and Francisco Javier Cubero and Hermann Elard Wasmuth},
  journal={Journal of hepatology},
  year={2009},
  volume={50 2},
  pages={370-6}
}
BACKGROUND/AIMS YKL-40 is a chitinase-like protein involved in matrix remodelling and a non-invasive fibrosis marker. We assessed whether a functional promoter polymorphism in CHI3L1, encoding YKL-40, is associated with HCV-induced liver fibrosis and influences YKL-40 serum concentrations. METHODS The CHI3L1 -131G-->C promoter polymorphism was genotyped in two cohorts of HCV infected patients (n=440) by 5'-endonuclease assays. Histological fibrosis scores and YKL-40 serum levels (ELISA) were… CONTINUE READING

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YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C.

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Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.

The New England journal of medicine • 2008
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