• DOI:10.1093/hmg/ddr268
Corpus ID: 11525603

A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese.

@article{Iida2011AFV,
  title={A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese.},
  author={A. Iida and A. Takahashi and M. Kubo and S. Saito and N. Hosono and Y. Ohnishi and K. Kiyotani and T. Mushiroda and M. Nakajima and K. Ozaki and Toshihiro Tanaka and T. Tsunoda and Shuichi Oshima and M. Sano and T. Kamei and T. Tokuda and M. Aoki and K. Hasegawa and K. Mizoguchi and M. Morita and Yuji Takahashi and M. Katsuno and N. Atsuta and Hirohisa Watanabe and F. Tanaka and R. Kaji and I. Nakano and N. Kamatani and S. Tsuji and G. Sobue and Yusuke Nakamura and S. Ikegawa},
  journal={Human molecular genetics},
  year={2011},
  volume={20 18},
  pages={
          3684-92
        }
}

• A. Iida, A. Takahashi, +29 authors S. Ikegawa
• Published 2011
• Biology, Medicine
• Human molecular genetics

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons. Several susceptibility genes for ALS have been reported; however, ALS etiology and pathogenesis remain largely unknown. To identify further ALS-susceptibility genes, we conducted a large-scale case-control association study using gene-based tag single-nucleotide polymorphisms (SNPs). A functional SNP (rs2275294) was found to be significantly associated with ALS through a… Expand