A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

@article{Martinez2014AFV,
  title={A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT).},
  author={Erin E. Martinez and Amy K. Darke and Catherine M. Tangen and Phyllis J. Goodman and Jay H. Fowke and Eric A Klein and Sarki A. Abdulkadir},
  journal={Cancer prevention research},
  year={2014},
  volume={7 9},
  pages={950-7}
}
NKX3.1 is an androgen-regulated prostate tumor suppressor protein. We previously found that antioxidant administration (N-acetylcysteine) in the Nkx3.1 knockout mouse model promoted prostate epithelial proliferation, suggesting that NKX3.1 activity modifies the effect of antioxidant administration on prostate carcinogenesis. Interestingly, administration of the antioxidant vitamin E significantly increased prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT… CONTINUE READING

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