A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

  title={A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities},
  author={Yuta Kochi and Ryo Yamada and Akari Suzuki and John B Harley and Senji Shirasawa and Tetsuji Sawada and S -C Bae and Shinya Tokuhiro and Xiaotian Chang and Akihiro Sekine and Atsushi Takahashi and Tatsuhiko Tsunoda and Yozo Ohnishi and Kenneth M Kaufman and Changsoo Kang and Changwon Kang and Shigeru Otsubo and Wako Yumura and Akio Mimori and Takao Koike and Yusuke Nakamura and Takehiko Sasazuki and Kazuhiko Yamamoto},
  journal={Nature Genetics},
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease… 
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