A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

@article{Kochi2005AFV,
  title={A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities},
  author={Y. Kochi and R. Yamada and A. Suzuki and J. Harley and S. Shirasawa and T. Sawada and S. Bae and S. Tokuhiro and X. Chang and A. Sekine and A. Takahashi and T. Tsunoda and Y. Ohnishi and K. Kaufman and C. Kang and S. Otsubo and W. Yumura and A. Mimori and T. Koike and Yusuke Nakamura and T. Sasazuki and Kazuhiko Yamamoto},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={478-485}
}
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease… Expand

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