A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.

@article{Chay2002AFT,
  title={A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.},
  author={Christopher H Chay and Carlton R. Cooper and James D Gendernalik and Saravana M. Dhanasekaran and Arul M. Chinnaiyan and Mark A. Rubin and Alvin H Schmaier},
  journal={Urology},
  year={2002},
  volume={60 5},
  pages={
          760-5
        }
}
OBJECTIVES To identify genes important in prostate cancer metastatic to bone. Bone-specific metastasis is a common feature of prostate cancer and a significant cause of morbidity. METHODS To identify factors involved in organ-specific metastasis, we used cDNA microarray analysis to compare a bone-derived cell line, VCaP, with a soft tissue-derived cell line, DuCaP. Both cell lines were derived from the same patient and spontaneously passaged. RESULTS Forty-five genes were differentially… CONTINUE READING
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