A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway.

@article{Grueneberg2003AFS,
  title={A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway.},
  author={Dorre A. Grueneberg and Lourdes Pablo and Kang-Quan Hu and Paul Nordstrom August and Zhigang Weng and Jacqueline Papkoff},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 11},
  pages={3936-50}
}
beta-Catenin signaling plays an important role in the development of many organisms and has a key part in driving the malignant transformation of epithelial cells comprising a variety of cancers. beta-Catenin can activate gene expression through its association with transcription factors of the lymphoid enhancer factor 1 (LEF-1)/T-cell factor (TCF) family. We designed a screen in human cells to identify novel genes that activate a beta-catenin-LEF/TCF-responsive promoter and isolated the high… CONTINUE READING