A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

@article{Siegel2009AFS,
  title={A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis},
  author={Gabriele Siegel and Gregor Obernosterer and Roberto Fiore and Martin Oehmen and Silvia Bicker and Mette Buskj{\ae}r Christensen and Sharof A. Khudayberdiev and Philipp J.F. Leuschner and Clara Jana-Lui Busch and Christina G. Kane and Katja H{\"u}bel and Frank J Dekker and Christian Hedberg and Balamurugan Rengarajan and Carsten Drepper and Herbert Waldmann and Sakari Kauppinen and Michael E. Greenberg and Andreas Draguhn and Marc Rehmsmeier and Javier Mart{\'i}nez and Gerhard Schratt},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={705-716}
}
The microRNA pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine morphogenesis, a phenomenon associated with long-lasting forms of memory. However, the particular microRNAs (miRNAs) involved are largely unknown. Here we identify specific miRNAs that function at synapses to control dendritic spine structure by performing a functional screen. One of the identified miRNAs, miR-138, is highly enriched in the brain, localized within dendrites… CONTINUE READING
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