A functional screen identifies lateral transfer of beta-glucuronidase (gus) from bacteria to fungi.

@article{Wenzl2005AFS,
  title={A functional screen identifies lateral transfer of beta-glucuronidase (gus) from bacteria to fungi.},
  author={Peter Wenzl and Laurie Wong and Kim Kwang-won and Richard A. Jefferson},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 2},
  pages={308-16}
}
Lateral gene transfer (LGT) from prokaryotes to microbial eukaryotes is usually detected by chance through genome-sequencing projects. Here, we explore a different, hypothesis-driven approach. We show that the fitness advantage associated with the transferred gene, typically invoked only in retrospect, can be used to design a functional screen capable of identifying postulated LGT cases. We hypothesized that beta-glucuronidase (gus) genes may be prone to LGT from bacteria to fungi (thought to… CONTINUE READING
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