A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

@article{Peeper2002AFS,
  title={A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence},
  author={Daniel S Peeper and A. L. Shvarts and Thijn R Brummelkamp and Sirith Douma and Eugene Y. Koh and George Q. Daley and Ren{\'e} Bernards},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={148-153}
}
Primary fibroblasts respond to activated H-RASV12 by undergoing premature arrest, which resembles replicative senescence. This irreversible 'fail-safe mechanism' requires p19ARF, p53 and the Retinoblastoma (Rb) family: upon their disruption, RASV12-expressing cells fail to undergo senescence and continue to proliferate. Similarly, co-expression of oncogenes such as c-MYC or E1A rescues RASV12-induced senescence. To identify novel genes that allow escape from RASV12-induced senescence, we… CONTINUE READING