A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers.

@article{Jeong2006AFS,
  title={A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers.},
  author={Yongsu Jeong and K{\^e}nia Balbi El-Jaick and Erich Roessler and Maximilian Muenke and Douglas J Epstein},
  journal={Development},
  year={2006},
  volume={133 4},
  pages={761-72}
}
The secreted protein sonic hedgehog (Shh) plays an integral role in forming the ventral midline of the vertebrate central nervous system (CNS). In the absence of Shh function, ventral midline development is perturbed resulting in holoprosencephaly (HPE), a structural malformation of the brain, as well as in neuronal patterning and path finding defects along the length of the anteroposterior neuraxis. Central to the understanding of ventral neural tube development is how Shh transcription is… CONTINUE READING
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