A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas.

@article{Saegusa2007AFR,
  title={A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas.},
  author={Makoto Saegusa and Miki Hashimura and Takeshi Kuwata and Mieko Hamano and Yoji Wani and Isao Okayasu},
  journal={Carcinogenesis},
  year={2007},
  volume={28 9},
  pages={1885-92}
}
Nuclear beta-catenin is required for changes in morphology from glandular to morular phenotypes of endometrial carcinoma (Em Ca) cells, with activation of p14(ARF)/p53/p21(Waf1) and alteration of p16(INK4A)/pRb pathways. Having demonstrated previously that the homeodomain transcription factor Cdx2 increases markedly during intestinal epithelial cell differentiation, we have examined its effects in beta-catenin signaling during transdifferentiation of Em Ca cells. In clinical cases, Cdx2… CONTINUE READING

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