A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling.

Abstract

Mannose 6-phosphate receptors (MPRs) deliver newly synthesized lysosomal enzymes to endosomes and then recycle to the Golgi. MPR recycling requires Rab9 GTPase; Rab9 recruits the cytosolic adaptor TIP47 and enhances its ability to bind to MPR cytoplasmic domains during transport vesicle formation. Rab9-bearing vesicles then fuse with the trans-Golgi network… (More)

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Cite this paper

@article{Reddy2006AFR, title={A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling.}, author={Jonathan V. Reddy and Alondra Schweizer Burguete and Khambhampaty Sridevi and Ian G Ganley and Ryan M. Nottingham and Suzanne R Pfeffer}, journal={Molecular biology of the cell}, year={2006}, volume={17 10}, pages={4353-63} }