A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.

@article{Bahia2005AFR,
  title={A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.},
  author={Parmvir K. Bahia and Rie Suzuki and David Charles Hammond Benton and Amanda J Jowett and Mao Xiang Chen and Derek J. Trezise and Anthony Henry Dickenson and Guy William John Moss},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 14},
  pages={3489-98}
}
We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord. Subunit-specific antibodies reveal high levels of SK3 immunoreactivity in laminas I, II, and III of the spinal cord. Among dorsal root ganglion neurons, both peripherin-positive (C-type) and peripherin-negative (A-type) cells show intense SK3 immunoreactivity… CONTINUE READING
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The SK 3 subunit of small conductance Ca 2  - activated K  channels interacts with both SK 1 and SK 2 subunits in a heterologous expression system

  • AS Monaghan, Benton DCH, +4 authors Moss GWJ
  • J Biol Chem
  • 2004
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