A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.

@article{Caruso2007AFR,
  title={A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.},
  author={Roberta Caruso and Daniele Fina and Ilaria Peluso and Carmine Stolfi and Massimo Claudio Fantini and Valentina Gioia and Flavio Andrea Caprioli and Giovanna Del Vecchio Blanco and Omero Alessandro Paoluzi and Thomas Macdonald and Francesco Pallone and Giovanni Monteleone},
  journal={Gastroenterology},
  year={2007},
  volume={132 1},
  pages={166-75}
}
BACKGROUND & AIMS Interleukin (IL)-21, a T-cell-derived cytokine, is produced in excess in inflammatory bowel diseases (IBD). The IL-21 receptor (IL-21R) is expressed by immune and nonimmune cells, raising the possibility that IL-21 has broad effects in gut inflammation. In this study we examined whether intestinal epithelial cells express IL-21R and respond to IL-21 in IBD. METHODS IL-21R was evaluated in intestinal samples of IBD patients and controls by immunohistochemistry and Western… CONTINUE READING