A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA.

@article{Andino1990AFR,
  title={A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA.},
  author={Raul Andino and Gabrielle E. Rieckhof and David Baltimore},
  journal={Cell},
  year={1990},
  volume={63 2},
  pages={369-80}
}
The existence of a computer-predicted cloverleaf structure for the first 100 nucleotides at the 5' end of poliovirus RNA was verified by site-directed mutagenesis and by chemical and RNAase probing. Mutations that modified the cloverleaf in the positive strand but not the negative strand were lethal to the virus. This RNA cloverleaf structure binds a cellular protein and the viral proteins 3Cpro and 3Dpol. Mutations in specific regions of the RNA cloverleaf prevented this binding. Mutations in… CONTINUE READING
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