A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

@inproceedings{Wiegand2013AFP,
  title={A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation},
  author={Kimberly C. Wiegand and Bryan T. J. Hennessy and Samuel Leung and Yemin Wang and Zhenlin Ju and Mollianne McGahren and Steve E Kalloger and Sarah Finlayson and Katherine Stemke-Hale and Yiling Lu and Fan Zhang and Michael S Anglesio and Blake C. Gilks and Gordon B Mills and David Huntsman and Mark S. Carey},
  booktitle={BMC Cancer},
  year={2013}
}
  • Kimberly C. Wiegand, Bryan T. J. Hennessy, +13 authors Mark S. Carey
  • Published in BMC Cancer 2013
  • Biology, Medicine
  • BackgroundOvarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC… CONTINUE READING

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    ARID1A loss in cancer: Towards a mechanistic understanding

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 41 REFERENCES

    ARID1A mutations in endometriosis-associated ovarian carcinomas.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Significance analysis of microarrays applied to the ionizing radiation response.

    VIEW 11 EXCERPTS
    HIGHLY INFLUENTIAL

    Predicting time to ovarian carcinoma recurrence using protein markers.

    VIEW 1 EXCERPT

    The clinicopathologic significance of BAF250a (AIRD1A) expression in clear cell carcinomas of the endometrium

    • O Fadare, K Gwin, +8 authors V Parkash
    • Mol Pathol
    • 2013
    VIEW 1 EXCERPT

    Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.

    VIEW 2 EXCERPTS