A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer.

@article{Varadi2009AFP,
  title={A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer.},
  author={Verena Varadi and Annika Brendle and Ewa Anna Grzybowska and Robert Johansson and Kerstin Enquist and Dorota Butkiewicz and Jolanta Pamula-Pilat and Wioletta Pękala and Kari Hemminki and Per Lenner and Asta Foersti},
  journal={Cancer genetics and cytogenetics},
  year={2009},
  volume={190 2},
  pages={71-4}
}
Telomere dysfunction is a key mechanism in cancer development. The human telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of the telomerase enzyme, which is necessary for the maintenance of telomere DNA length, chromosomal stability, and cellular immortality. In our attempt to identify functional polymorphisms in the TERT gene… CONTINUE READING