A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance

@article{Yasuda2014AFP,
  title={A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance},
  author={Yuka Yasuda and Ryota Hashimoto and Kazutaka Ohi and Hidenaga Yamamori and Hiroshi Ichinose},
  journal={Neuroscience Letters},
  year={2014},
  volume={566},
  pages={46-49}
}
Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin, a cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. As monoamine neurotransmitters are synthesized by the reactions catalyzed by tyrosine hydroxylase and tryptophan hydroxylase, alterations in the content of tetrahydrobiopterin affect the monoamine levels in the brain. Here, we examined the possible association of a functional single-nucleotide… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

J

L. Zhang, F. Rao, +6 authors D. W. Smith
  • Wessel, R.M. Salem, J.L. Rodriguez-Flores, S.K. Mahata, N.J. Schork, M.G. Ziegler, D.T. O‘Connor, Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk, J. Clin. Invest. 117
  • 2007
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A functional polymorphism ( C824 T ) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia

C. Sumiyoshi, T. Sumiyoshi, +6 authors O. Imura
  • Psychiatry Clin . Neurosci .
  • 2014

Performance on the Wechsler Adult Intelligence scalethird edition in Japanese patients with schizophrenia

M. Fukumoto, R. Hashimoto, +6 authors M. Takeda
  • Psychiatry Clin . Neurosci .
  • 2014