A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.


Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin, a cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. As monoamine neurotransmitters are synthesized by the reactions catalyzed by tyrosine hydroxylase and tryptophan hydroxylase, alterations in the content of… (More)
DOI: 10.1016/j.neulet.2014.02.019


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