A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes

@article{Bassuny2003AFP,
  title={A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes},
  author={Wafaa M. Bassuny and Kenji Ihara and Yuka Sasaki and Ryuichi Kuromaru and Hitoshi Kohno and Nobuo Matsuura and Toshiro Hara},
  journal={Immunogenetics},
  year={2003},
  volume={55},
  pages={149-156}
}
FOXP3/Scurfin, a member of forkhead/winged-helix proteins, is involved in the regulation of T-cell activation, and essential for normal immune homeostasis. The FOXP3/Scurfin gene is located on chromosome Xp11.23, which includes one of the type 1 diabetes susceptible loci. Therefore, we investigated whether the human FOXP3/Scurfin gene might be a new candidate gene for type 1 diabetes. We first screened the human FOXP3/Scurfin gene for microsatellite and single nucleotide polymorphisms. Next, we… 

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