A functional polymorphism in the monoamine oxidase A gene promoter

@article{Sabol1998AFP,
  title={A functional polymorphism in the monoamine oxidase A gene promoter},
  author={Sue Z. Sabol and Stella Hu and Dean Hamer},
  journal={Human Genetics},
  year={1998},
  volume={103},
  pages={273-279}
}
Abstract We describe a new polymorphism upstream of the gene for monoamine oxidase A (MAOA), an important enzyme in human physiology and behavior. The polymorphism, which is located 1.2 kb upstream of the MAOA coding sequences, consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism is in linkage disequilibrium with other MAOA and MAOB gene markers and displays significant variations in allele frequencies across ethnic groups. The polymorphism has been shown to… 

A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders

It is suggested that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression, and no association between the polymorphism and a history of suicide attempt is found.

Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.

There is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in the population of patients tested.

Functional variation in promoter region of monoamine oxidase A and subtypes of alcoholism: Haplotype analysis

The results indicate that MAO‐A may play a role in the development of alcoholism but the gene effect is very small.

Monoamine oxidase A (MAOA) gene polymorphism in offenders and psychiatric patients in an Egyptian Study

Findings suggest that either high or low activity alleles of the MAOA-uVNTR 30-bp polymorphism are not associated with antisocial behavior in offenders or psychiatric patients.

Assessment of the Role of a Functional VNTR Polymorphism in MAOA Gene Promoter: A Preliminary Study

To further look into the uVNTR polymorphism among the Asian population and to preliminarily investigate its transcriptional function, functional characterization in a luciferase assay demonstrated that the 2-repeat allele was more active than others.

Investigation of the functional effect of monoamine oxidase polymorphisms in human brain

The results suggest that a novel functional polymorphism that affects enzyme activity in human brain may exist in MAOA, and postulate that there may be a cis-regulatory element in linkage disequilibrium with the B-SNP13 polymorphisms that alters MAOB enzyme activityIn human brain.

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder.

It is found that none of the different repeat copies was preferentially transmitted from mothers to their children affected with bipolar disorder and a non-significant trend for patients with an ultra-rapid cycling form of illness to have a higher frequency of low-activity alleles is found.

Polymorphisms in the canine monoamine oxidase a (MAOA) gene: identification and variation among five broad dog breed groups

Dogs exhibit significant variation in certain intronic regions of the MAOA gene, while the coding and promoter regions are well-conserved, perhaps attributable to canine domestication and recent breed formation.
...

References

SHOWING 1-10 OF 51 REFERENCES

The promoter of the human monoamine oxidase A gene.

  • R. Denney
  • Biology
    Progress in brain research
  • 1995

Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism.

Structure of the human gene for monoamine oxidase type A.

This work isolated human genomic clones spanning almost all the MAOA gene from cosmid and phage libraries using a cDNA probe for MAO-A and demonstrated that the longer message has an extension of 2.2 kb in the 3' noncoding region and appears to be generated by the use of two alternative polyadenylation sites.

Structure and promoter organization of the human monoamine oxidase A and B genes.

These findings suggest that the MAOA and MAOB genes are derived from the duplication of a common ancestral gene.

Promoter organization and activity of human monoamine oxidase (MAO) A and B genes

The different promoter organization of MAO A and B genes provides the basis for their different tissue- and cell- specific expression.

A New Look at the Promoter of the Human Monoamine Oxidase A Gene: Mapping Transcription Initiation Sites and Capacity to Drive Luciferase Expression

It is concluded that the primary transcription initiation site occurs at a putative initiator (Inr) element located between −30 and −40, with a minor, tissue‐specific proportion of additional initiation near −95 and −136, and that MAO A‐luciferase reporter constructs that contained all the known transcription initiation sites exhibited no evidence for inhibitory cis elements between −200 and at least −935.

An Extensive Repeat Structure Down‐Regulates Human Monoamine Oxidase A Promoter Activity Independent of an Initiator‐Like Sequence

The results suggest that although the Inr‐like sequence is present in the human MAO A promoter, it acts as a negative cis element instead of a transcription initiator.

Identification of human monoamine oxidase (MAO) A and B gene promoters.

The promoter of human monoamine oxidase (MAO) A and B genes have been identified and the different organization of the MAO A and A promoters may underlie their different cell and tissue specific expression.
...