A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis.

@article{Shen2008AFP,
  title={A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis.},
  author={Jie Shen and Christine B. Ambrosone and Richard A. Dicioccio and Kunle O Odunsi and Shashikant B. Lele and Hua Zhao},
  journal={Carcinogenesis},
  year={2008},
  volume={29 10},
  pages={1963-6}
}
A G to C polymorphism (rs2910164) is located within the sequence of miR-146a precursor, which leads to a change from a G:U pair to a C:U mismatch in its stem region. The predicted miR-146a target genes include BRCA1 and BRCA2, which are key breast and ovarian cancer genes. To examine whether rs2910164 plays any role in breast and/or ovarian cancer, we studied associations between this polymorphism and age of diagnosis in 42 patients with familial breast cancer and 82 patients with familial… CONTINUE READING
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