A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

@inproceedings{Espinoza2016AFP,
  title={A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers},
  author={J Luis Espinoza and Viet Huy Nguyen and Hiroshi Ichimura and Trang Thuy Pham and Cuong Hung Nguyen and Thuc Van Pham and Mahmoud Ibrahim Yousef Elbadry and Katsuji Yoshioka and Junji Tanaka and Ly Quoc Trung and Akiyoshi Takami and Shinji Nakao},
  booktitle={Scientific reports},
  year={2016}
}
Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. NKG2D, an activating receptor expressed by NK cells, plays an important role in cancer immune-surveillance. We analyzed the impact of a NKG2D gene variant, rs1049174, on the incidence of HPV-related cancers in Vietnamese patients and utilized various molecular approaches to elucidate the mechanisms of NKG2D receptor regulation… CONTINUE READING
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