A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis A.

@article{Hoehler2005AFP,
  title={A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis A.},
  author={Thomas Hoehler and Esther Reuss and Christine M. Freitag and Peter M. Schneider},
  journal={Hepatology},
  year={2005},
  volume={42 1},
  pages={
          72-6
        }
}
The immune response to hepatitis B surface antigen (HBsAg) is mostly genetically determined. Interleukin 10 (IL-10) is a central immunoregulatory cytokine with important effects on B-cells. We have studied the influence of IL-10 promoter polymorphisms on the immune response to HBsAg and hepatitis A vaccination. We vaccinated 202 twin pairs in an open prospective study with a combined recombinant HBsAg/inactivated hepatitis A vaccine. IL-10 promoter polymorphisms were investigated in all… CONTINUE READING

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