A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease.

@article{Vries2012AFP,
  title={A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease.},
  author={Hilbert S. de Vries and Rene te Morsche and Kevin Jenniskens and Wilbert H. M. Peters and Dirk J de Jong},
  journal={Journal of Crohn's & colitis},
  year={2012},
  volume={6 5},
  pages={597-602}
}
BACKGROUND An imbalance between the production of reactive oxygen species (ROS) and their capturing by antioxidants results in oxidative stress, this may play an important role in the pathogenesis of inflammatory bowel disease (IBD). Since bilirubin is an important endogenous antioxidant, increased levels of bilirubin may protect against IBD. UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene… CONTINUE READING
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