A functional polymorphism in IL-1A gene is associated with a reduced risk of gastric cancer

@article{Zeng2013AFP,
  title={A functional polymorphism in IL-1A gene is associated with a reduced risk of gastric cancer},
  author={Xiaofeng Zeng and Juan Li and Sheng-Bin Li},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={265-268}
}
Accumulating evidence has identified that polymorphism residing in the microRNA (miRNA) binding site of target genes can affect the strength of miRNA binding and influence individual susceptibility to cancer. Recently, an insertion/deletion polymorphism (rs3783553 ttca/-) at miRNA-122 binding site in the interleukin-1A 3′ untranslated region has been demonstrated to be functional. We aimed to investigate the association between the rs3783553 polymorphism and the risk of gastric cancer (GC). We… CONTINUE READING