A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.

@article{Liang2011AFP,
  title={A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.},
  author={C Liang and Edward Hsi and Ku-Chung Chen and Yun-Ru Pan and Yung-Song Wang and S. H. Juo},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 6},
  pages={3500-5}
}
PURPOSE The paired box 6 (PAX6) is involved in eye development and associated with several ocular diseases. Conflicting results have been reported regarding the association between PAX6 polymorphism and myopia. This case-control study and functional assay were conducted to identified a functional risk polymorphism for myopia. METHODS The study cohort included 1083 cases (≤ -6.0 D) and 1096 controls (≥ -1.5 D) from a Chinese population residing in Taiwan. Four common tag single-nucleotide… CONTINUE READING

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