A functional polymorphism (-347 G-->GA) in the E-cadherin gene is associated with colorectal cancer.

@article{Shin2004AFP,
  title={A functional polymorphism (-347 G-->GA) in the E-cadherin gene is associated with colorectal cancer.},
  author={Yong Chan Shin and Il-Jin Kim and Hio Chung Kang and Jae-Hyun Park and Hye-won Park and Sang-Geun Jang and Min Ro Lee and Seung-Yong Jeong and Hee Jin Chang and Ja-Lok Ku and J L Park},
  journal={Carcinogenesis},
  year={2004},
  volume={25 11},
  pages={2173-6}
}
E-cadherin, the main adhesion molecule of epithelial cells, has been implicated in carcinogenesis because its expression is frequently lost in human epithelial cancers. E-cadherin protein expression is significantly reduced in sporadic colorectal cancers (CRC), but apparently not as a consequence of allele loss or somatic mutation. We reported recently that a single nucleotide polymorphism (-347 G-->GA) in the E-cadherin promoter suppressed E-cadherin expression and was associated with familial… CONTINUE READING

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