A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

  title={A functional network involved in the recycling of nucleocytoplasmic pre-60S factors},
  author={Alice Lebreton and Cosmin Saveanu and Laurence Decourty and J J Rain and Alain Jacquier and Micheline Fromont-Racine},
  journal={The Journal of Cell Biology},
  pages={349 - 360}
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in… CONTINUE READING

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Publications referenced by this paper.
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60S preribosome formation viewed from assembly in the nucleolus until export to the cytoplasm

T. A. Nissan, J. Bassler, E. Petfalski, D. Tollervey, E. Hurt.
EMBO J. 21:5539–5547. • 2002
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