A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

@article{Lebreton2006AFN,
  title={A functional network involved in the recycling of nucleocytoplasmic pre-60S factors},
  author={Alice Lebreton and Cosmin Saveanu and Laurence Decourty and J J Rain and Alain Jacquier and Micheline Fromont-Racine},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={173},
  pages={349 - 360}
}
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in… CONTINUE READING

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