A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus.

@article{Wiskott2006AFH,
  title={A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus.},
  author={Laurenz Wiskott and Malte J. Rasch and Gerd Kempermann},
  journal={Hippocampus},
  year={2006},
  volume={16 3},
  pages={329-43}
}
The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of catastrophic interference when adapting to new environments. We assume that old neurons are rather stable and preserve an optimal encoding learned for known environments while new neurons are plastic to adapt to… CONTINUE READING
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