A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells.

@article{Fischer2014AFH,
  title={A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells.},
  author={Simon Fischer and Theresa Buck and Andreas Wagner and Carolin Ehrhart and Julia Giancaterino and Samuel Mang and Matthias Schad and Sven Mathias and Armaz Aschrafi and Ren{\'e} Handrick and Kerstin Otte},
  journal={Biotechnology journal},
  year={2014},
  volume={9 10},
  pages={
          1279-92
        }
}
The steady improvement of mammalian cell factories for the production of biopharmaceuticals is a key challenge for the biotechnology community. Recently, small regulatory microRNAs (miRNAs) were identified as novel targets for optimizing Chinese hamster ovary (CHO) production cells as they do not add any translational burden to the cell while being capable of regulating entire physiological pathways. The aim of the present study was to elucidate miRNA function in a recombinant CHO-SEAP cell… CONTINUE READING
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-9 of 9 citations