A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.

@article{Zhao2012AFG,
  title={A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.},
  author={Hong Zhao and Wenyu Lin and Kattareeya Kumthip and Du Cheng and Dahlene Fusco and Oliver Hofmann and Nikolaus Jilg and Andrew W Tai and Kaku Goto and Leiliang Zhang and Winston A Hide and Jae Young Jang and Lee F. Peng and Raymond Tsang Chi Chung},
  journal={Journal of hepatology},
  year={2012},
  volume={56 2},
  pages={326-33}
}
BACKGROUND & AIMS The precise mechanisms by which IFN exerts its antiviral effect against HCV have not yet been elucidated. We sought to identify host genes that mediate the antiviral effect of IFN-α by conducting a whole-genome siRNA library screen. METHODS High throughput screening was performed using an HCV genotype 1b replicon, pRep-Feo. Those pools with replicate robust Z scores ≥2.0 entered secondary validation in full-length OR6 replicon cells. Huh7.5.1 cells infected with JFH1 were… CONTINUE READING
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