A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.

@article{Tai2009AFG,
  title={A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.},
  author={Andrew W Tai and Yair Benita and Lee F. Peng and Sun-Suk Kim and Naoya Sakamoto and Ramnik J. Xavier and Raymond Tsang Chi Chung},
  journal={Cell host & microbe},
  year={2009},
  volume={5 3},
  pages={298-307}
}
Hepatitis C virus (HCV) chronically infects 3% of the world's population, and complications from HCV are the leading indication for liver transplantation. Given the need for better anti-HCV therapies, one strategy is to identify and target cellular cofactors of the virus lifecycle. Using a genome-wide siRNA library, we identified 96 human genes that support HCV replication, with a significant number of them being involved in vesicle organization and biogenesis. Phosphatidylinositol 4-kinase… CONTINUE READING
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