A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.

@article{David2005AFG,
  title={A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.},
  author={Sean P. David and N. V. Murthy and Eugenii A. Rabiner and Marcus R Munaf{\`o} and Elaine C. Johnstone and Robyn M Jacob and Robert T. Walton and Paul M. Grasby},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 10},
  pages={2586-90}
}
In humans, 5-HT1A receptors are implicated in anxiety and depressive disorders and their treatment. However, the physiological and genetic factors controlling 5-HT1A receptor expression are undetermined in health and disease. In this study, the influence of two genetic factors on 5-HT1A receptor expression in the living human brain was assessed using the 5-HT1A-selective positron emission tomography (PET) ligand [11C]WAY 100635. After the genotyping of 140 healthy volunteers to study population… CONTINUE READING
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