A functional genetic variation of the 5-HT2a receptor affects human memory

@article{Quervain2003AFG,
  title={A functional genetic variation of the 5-HT2a receptor affects human memory},
  author={Dominique J-F de Quervain and Katharina Henke and Amanda Aerni and Daniel Coluccia and Marc Axel Wollmer and Christoph Hock and Roger M. Nitsch and Andreas Papassotiropoulos},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={1141-1142}
}
Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.