A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer.

@article{Liu2012AFC,
  title={A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer.},
  author={Bing Liu and Lei Yang and Binfang Huang and Mei Qing Cheng and Hui Wang and Yinyan Li and Dongsheng Huang and Jian Zheng and Qingchu Li and Xin Zhang and Wei-dong Ji and Yifeng Zhou and Jiachun Lu},
  journal={American journal of human genetics},
  year={2012},
  volume={91 2},
  pages={384-90}
}
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) may promote cancer development and progression by inducing tumorigenesis and drug resistance. To assess whether the copy-number variation g.CNV-30450 located in the MAPKAPK2 promoter has any effect on lung cancer risk or prognosis, we investigated the association between g.CNV-30450 and cancer risk in three independent case-control studies of 2,332 individuals with lung cancer and 2,457 controls and the effects of g.CNV… CONTINUE READING
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