A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.

  title={A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.},
  author={Michael L. Mucenski and K L McLain and Ann B. Kier and Steven H Swerdlow and Claire M. Schreiner and Thomas A. Miller and Daniel W. Pietryga and William J. Scott and S. Steven Potter},
  volume={65 4},
The c-myb proto-oncogene encodes a sequence-specific DNA-binding protein. To better understand its normal biological function, we have altered the c-myb gene by homologous recombination in mouse embryonic stem cells. Resulting homozygous c-myb mutant mice displayed an interesting phenotype. At day 13 of gestation these mice appeared normal, suggesting that c-myb is not essential for early development. By day 15, however, the mutant mice were severely anemic. Analysis indicated that embryonic… CONTINUE READING
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