A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.

@article{Mototani2008AFS,
  title={A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.},
  author={Hideyuki Mototani and Aritoshi Iida and Masahiro Nakajima and Tatsuya Furuichi and Yoshinari Miyamoto and Tatsuhiko Tsunoda and Akihiro Sudo and Akihiro Kotani and Atsumasa Uchida and K. Ozaki and Yoshiya Tanaka and Yusuke Nakamura and Toshihiro Tanaka and Kohei Notoya and Shiro Ikegawa},
  journal={Human molecular genetics},
  year={2008},
  volume={17 12},
  pages={1790-7}
}
Osteoarthritis (OA) is the most common form of arthritis and is characterized by the gradual loss of articular cartilage. Several OA-susceptibility genes have been identified; however, there are few pharmaceutical targets that can be targeted with small-molecule compounds. To investigate whether a susceptibility gene for OA exists among G-protein-coupled receptors (GPCRs), we performed a stepwise association study for 167 single nucleotide polymorphisms (SNPs) in 44 GPCR genes that were present… CONTINUE READING
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The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis

  • G. N. Smith, Jr.
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