A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling

@article{Friedman2006AFR,
  title={A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling},
  author={Adam A. Friedman and Norbert Perrimon},
  journal={Nature},
  year={2006},
  volume={444},
  pages={230-234}
}
Receptor tyrosine kinase (RTK) signalling through extracellular-signal-regulated kinases (ERKs) has pivotal roles during metazoan development, underlying processes as diverse as fate determination, differentiation, proliferation, survival, migration and growth. Abnormal RTK/ERK signalling has been extensively documented to contribute to developmental disorders and disease, most notably in oncogenic transformation by mutant RTKs or downstream pathway components such as Ras and Raf. Although the… CONTINUE READING

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Receptor tyrosine kinase ( RTK ) signalling through extracellular - signal - regulated kinases ( ERKs ) has pivotal roles during metazoan development , underlying processes as diverse as fate determination , differentiation , proliferation , survival , migration and growth .
Receptor tyrosine kinase ( RTK ) signalling through extracellular - signal - regulated kinases ( ERKs ) has pivotal roles during metazoan development , underlying processes as diverse as fate determination , differentiation , proliferation , survival , migration and growth .
Receptor tyrosine kinase ( RTK ) signalling through extracellular - signal - regulated kinases ( ERKs ) has pivotal roles during metazoan development , underlying processes as diverse as fate determination , differentiation , proliferation , survival , migration and growth .
Receptor tyrosine kinase ( RTK ) signalling through extracellular - signal - regulated kinases ( ERKs ) has pivotal roles during metazoan development , underlying processes as diverse as fate determination , differentiation , proliferation , survival , migration and growth .
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