A functional Notch–survivin gene signature in basal breast cancer

@article{Lee2008AFN,
  title={A functional Notch–survivin gene signature in basal breast cancer},
  author={Connie W.C. Lee and Karl J. Simin and Qin Liu and Janet Plescia and Minakshi Guha and Ashraf Ullah Khan and Chung-Cheng Hsieh and Dario C. Altieri},
  journal={Breast Cancer Research : BCR},
  year={2008},
  volume={10},
  pages={R97 - R97}
}
Basal-type, or triple-negative, breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high-risk disease for which no molecular therapies are currently available. We studied genetic signatures of basal breast cancer potentially suitable for therapeutic intervention. We analyzed protein expression of the Notch-1 intracellular domain and survivin by immunohistochemistry in a series of basal breast cancer patients. A… CONTINUE READING