A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.

@article{Nebel2009AFE,
  title={A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.},
  author={Almut Nebel and Friederike Flachsbart and Andreas Till and Amke Caliebe and H{\'e}l{\`e}ne Blanch{\'e} and Alexander Arlt and Robert H{\"a}sler and Gunnar Jacobs and Rabea Kleindorp and Andre Franke and Binghui Shen and Susanna Nikolaus and Michael Krawczak and Philip Rosenstiel and Stefan Schreiber},
  journal={Mechanisms of ageing and development},
  year={2009},
  volume={130 10},
  pages={691-9}
}
Human longevity is heritable with a genetic component of 25-32%. Variation in genes regulating the levels of somatic maintenance and DNA repair functions is thought to modulate the aging process and to contribute to survival at advanced age. We tested 92 non-synonymous SNPs in 49 DNA repair genes for a possible association with longevity in a sample of 395 German centenarians and 411 controls. The obtained association signal in exonuclease 1 (EXO1) was further investigated by fine mapping and… CONTINUE READING
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