A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.

@article{Lu2015AFF,
  title={A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.},
  author={Hao Lu and Meng Tiak Toh and Vijayashankaranarayanan Narasimhan and Surin Kumar Thamilselvam and Semil P. Choksi and Sudipto Kumar Roy},
  journal={Developmental biology},
  year={2015},
  volume={397 2},
  pages={225-36}
}
Cilia perform a variety of functions in a number of developmental and physiological contexts, and are implicated in the pathogenesis of a wide spectrum of human disorders. While the ciliary axoneme is assembled by intraflagellar transport, how ciliary membrane length is regulated is not completely understood. Here, we show that zebrafish embryos as well as mammalian cells overexpressing the ciliary membrane protein Arl13b, an ARF family small GTPase that is essential for ciliary differentiation… CONTINUE READING

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