A function for REM sleep: regulation of noradrenergic receptor sensitivity

@article{Siegel1988AFF,
  title={A function for REM sleep: regulation of noradrenergic receptor sensitivity},
  author={Jerome M Siegel and Michael A Rogawski},
  journal={Brain Research Reviews},
  year={1988},
  volume={13},
  pages={213-233}
}
We hypothesize that REM sleep serves to upregulate and/or prevent downregulation of brain norepinephrine (NE) receptors. This hypothesis is based on the following observations: (1) NE neurons of the locus coeruleus (LC) are tonically active in waking and non-REM sleep, but the entire population of LC NE neurons is inactive during REM sleep. (2) Continuous presence of NE or adrenoceptor agonists downregulates NE receptors, while a reduction in NE availability upregulates these receptors. (3) The… CONTINUE READING

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