A function for REM sleep: regulation of noradrenergic receptor sensitivity

  title={A function for REM sleep: regulation of noradrenergic receptor sensitivity},
  author={Jerome M Siegel and Michael A Rogawski},
  journal={Brain Research Reviews},
We hypothesize that REM sleep serves to upregulate and/or prevent downregulation of brain norepinephrine (NE) receptors. This hypothesis is based on the following observations: (1) NE neurons of the locus coeruleus (LC) are tonically active in waking and non-REM sleep, but the entire population of LC NE neurons is inactive during REM sleep. (2) Continuous presence of NE or adrenoceptor agonists downregulates NE receptors, while a reduction in NE availability upregulates these receptors. (3) The… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 173 references

Recovery from chronic sleep deprivation in the rat

  • C. A. Everson, C. A. Kushida, +4 authors A. Rechtschaffen
  • Sleep Res.,
  • 1987

Sleep-wake cycle and sensitivity to drugs acting on adrenergic receptors after DSP-4, a selective noradrenergic neurotoxin

  • J. M. Monti, T. Pellejero, H. Jantos, L. D'Angelo, L. Barbeito, V. Abo
  • Sleep Res.,
  • 1987

Spike firing of single locus coeruleus neurons during experimental epileptic seizures in the rat

  • S. Yamaguchi, M. A. Rogawski
  • Soc. Neurosd. Abstr.,
  • 1987

Similar Papers

Loading similar papers…