A function essential to viral entry underlies the hepatitis B virus "a" determinant.

@article{Salisse2009AFE,
  title={A function essential to viral entry underlies the hepatitis B virus "a" determinant.},
  author={Jessica Salisse and Camille Sureau},
  journal={Journal of virology},
  year={2009},
  volume={83 18},
  pages={
          9321-8
        }
}
The hepatitis B virus (HBV) particles bear a receptor-binding site located in the pre-S1 domain of the large HBV envelope protein. Using the hepatitis delta virus (HDV) as a surrogate of HBV, a second infectivity determinant was recently identified in the envelope proteins antigenic loop (AGL), and its activity was shown to depend upon cysteine residues that are essential for the structure of the HBV immunodominant "a" determinant. Here, an alanine-scanning mutagenesis approach was used to… CONTINUE READING
BETA

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